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NAD+ is a coenzyme present in every living cell, central to the redox reactions that generate cellular energy and required as a substrate by sirtuins and PARP enzymes that regulate gene expression and DNA repair.
Studies measuring NAD+ across age groups have found substantially lower levels in older adults compared to younger ones, a decline linked to reduced sirtuin activity and slower DNA repair in aging models.
This has made NAD+ metabolism a central focus of research into cellular aging, mitochondrial function, and genomic stability.
