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GHRP-6 is a synthetic hexapeptide that activates the ghrelin receptor (GHS-R1a), the same receptor through which the natural hunger hormone ghrelin acts, producing strong pulses of growth hormone release.
Animal studies have found that GHRP-6 also stimulates food intake by activating orexigenic neurons in the hypothalamus, an effect more pronounced than with newer, more selective GH secretagogues.
This dual GH-releasing and appetite-stimulating profile is what keeps it a reference compound in ghrelin receptor and hypothalamic appetite research.
